Weekly Research Briefing: Mostly Green Except for the Occasional Velociraptor

December 16, 2025
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Your portfolio should be looking very good right now for 2025. Lots of positive returns with only specks of red. With three strong years in a row, your mental arguments are likely more about why you didn't have more invested in this better performing asset than the one that was only up with a single digit return. Don't beat yourself up about it. Enjoy another year of gains.

The last big scheduled event of the year was the December FOMC meeting. As somewhat expected, they did cut the Fed Funds rate 25bps one more time. With viewpoints breaking out in opposite directions, it now looks like the FOMC will now enter into a holding pattern on future rate decisions until the economy makes a meaningful move in either direction. The bond market would like to see one 25bp cut in the spring of 2026 and another later in the year.

Oracle's earnings were the other big event last week, and they did not disappoint the AI bears. Oracle took up its capex spending both currently and into 2026 but did little in the way of significantly expanding its future AI revenue book or its customer diversification. Oracle, for now, will remain an OpenAI story. This isn't a bad thing as long as ChatGPT starts blasting some home runs.

This week the market will have its final run of economic data and earnings before the year-end holidays shut us down until January. On deck is the November and October delayed non-farm payroll release on Tuesday, two months of CPI being released on Thursday along with the Philly Fed. And existing home sales on Friday. For earnings, we will get consumer reads out of Nike, Carnival Cruise and Lennar Homes. FedEx and Micron will also be of interest. Then that is it. The equity market typically has a year-end lift along with Santa's sleigh and the champagne bubbles. As the table below shows, the last 2 weeks of December and first 2 weeks of January, are typically good return windows.

One outstanding item is the Supreme Court's decision on the White House's tariffs. This could wait until January, or SCOTUS could dress up in red and give consumers, businesses and investors another holiday gift. Most think that the tariffs will be repealed, so an upward market move could be limited. Also, the WH says they will quickly act with new trade taxes that will continue to impact prices and hurt American customers. But if there is a positive decision over the break, look for the biggest rallies in tariff-sensitive businesses like apparel, furniture and autos. Also, some companies could receive a refund of taxes, but we have no idea on the estimate or the timing of these refunds.

Thanks for another great year of questions, comments, and ideas to make the WRB better. We will close the books on this 15th year of writing and get a fresh notepad out for what crosses our desk to write about in 2026. Have a great holiday and year end with your friends and families.


No longer a Mag-7 story as the rest of the equity market is lifting to new all-time highs… 

@RenMacLLC: The "breadth bear" case is impaired. S&P 500 Equal Weight hitting fresh highs confirms this isn't just a mega-cap story. When the average stock participates, the floor rises.


Here is a long list of broad ETFs (that you likely own) hitting all-time new highs on Friday… 

Plenty of representation from the International, Smaller Cap and more Cyclical weighted indexes. Even the Dow Jones Industrial showed up.

Barchart.com


A big reason for the strong returns in the US equity market has been the outperformance of Q3 earnings results which closed the books last week… 

Did you think that Health Care would have put up the most beats and fewest misses for the earnings period? Meanwhile, Consumer Discretionary was among the worst of the reporting sectors. This helps to explain the 1,000+ basis point difference in performance the last three months between the two sectors.

@EarningsScout: 3Q 2025 S&P 500 officially ended last night. All 500 co's have released results for either their August, September or October quarter ends. Here are the updated scorecards. EPS growth was +10.56% on +8.55% sales growth. Rock solid.


Now that was a good year… 

Congrats to Gold (and Silver, High Yield and Investment Grade Credit and Int'l Equities) for the outstanding risk adjusted returns in 2025. The US dollar, Crude Oil and Bitcoin the only losers.

Goldman Sachs


It looks as if the torch is being passed… 

Zooming in on the Mag-7 shows a much more muted performing group than in previous years with only two names beating the indexes year to date.

@LizAnnSonders


Goldman lifts the S&P 500 earnings figures over the weekend as they see AI-driven productivity gains helping out the gains of the other 493 companies… 

Turning it up to $300+. Ben Snider raises our 2026 S&P 500 EPS forecast by 9% to $305 against a backdrop of solid GDP growth, a weaker dollar, and alongside GS equity analyst forecasts for continued earnings strength among the largest technology stocks, as laid out in "US Equity Views: Economic acceleration and AI adoption should support solid S&P 500 EPS growth in 2026 and 2027." Focus on: revenue growth of 7% and margin expansion of 70 bp. And for 2027, we now forecast a further 10% increase in earnings to $336/share.

What's under the earnings hood? Mega-cap Tech should contribute a bit less to earnings growth in 2026 than it did this year. But AI-driven productivity gains will permeate across the S&P 500, lifting S&P 500 EPS by 0.4% in 2026 and 1.5% in 2027.

Goldman Sachs


The FOMC now moves into a holding pattern as the committee is divided and validated on both sides of their dual mandate… 

“Everyone around the table at the FOMC agrees that inflation is too high and we want it to come down, and agrees that the labor market has softened and that there is further risk. Everyone agrees on that. Where the difference is, is how do you weight those risks and what does your forecast look like and where do -- ultimately, where do you think the bigger risk is?” – Fed Chair Jerome Powell

The Transcript


The bond market now wants one cut in the spring and one in the fall… 

CME Group


US bank stocks will be enjoying the Fed's cuts at the short end of the curve while the market takes long rates higher… 

@lisaabramowicz1: Yield curves are steepening in the US as traders price in more rate cuts, with the gap between 2 and 10-year yields widening to the most since April.


More important good news for the US banks is that credit quality remains strong at the credit card companies… 

“And so we had thought that our charge-offs this year would come in around 3.6% for credit card...In fact, as I said, we’re actually expecting charge-offs now to be about 3.3%, a combination of a better macro-environment but also the fact that we are, you know, clearer about the impact of delayed charge-offs and feeling pretty good about the underlying financial health of the borrowers in our portfolio, which means if you look forward, just think about that as the starting point is call it shifted lower 30 basis points.” – JPMorgan Chase & Co Head of Strategic Growth Marianne Lake

“We haven’t seen anything at this point that would lead us to believe that there’s any sort of credit cycle or any softening. We watch it very, very carefully.” – American Express CEO Stephen Squeri

The Transcript


Consumers don't appear to be on the hunt for a new vehicle this year… 

Plans to buy a New Vehicle decreased to 39% vs. 43% in December 2024. It is down significantly from the recent peak of 45% in July and is lower than four previous Decembers.

BofA Global


People also seem to be sticking close to their existing employers as worries over employment grow… 

@lisaabramowicz1: The quits rate in October's JOLTS report came in at 1.8%, the lowest since May 2020. While the number of job openings increased, it seems that workers don't have much confidence to leave behind steady employment.


Monday's NY Fed Manufacturing figures read pretty mixed with new orders and shipments down, but future expectations higher… 

@LizAnnSonders: December Empire Manufacturing Index down to -3.9 vs. +10 est. & +18.7 prior; new orders 0 vs. +15.9 prior; shipments -5.7 vs. +16.8 prior; avg. workweek +3.5 vs. +7.7 prior; prices paid +37.6 vs. +49 prior; 6m expectations +35.7 vs. +19.1 prior; employment +7.3 vs. +6.6 prior


AI remains a major market theme…

Big chips are being placed right now with some pushing their stacks to the middle of the table, while others are taking theirs off the table. Count Apollo as being in the more conservative camp.

While Apollo has also judged AI as a potential opportunity for software companies, the group’s top leadership has decided to actively cut its exposure, believing that it should not be making directional industry bets.

“Technology change is going to cause massive dislocation in the credit market,” said Marc Rowan at a recent conference. “I don’t know whether that’s going to be enterprise software, which could […] benefit or be destroyed by this. As a lender, I’m not sure I want to be there to find out.”

Apollo has been rapidly cutting its lending commitments to the sector as a means of trimming risk through the course of the year.

Apollo entered 2025 with many of its private credit funds holding roughly 20 per cent exposure to software groups, but has cut that concentration by almost half, Rowan told some investors in private meetings at a Goldman Sachs conference on Wednesday, said a source who attended.

Apollo’s goal is to soon have its overall software exposure in its credit funds dip below 10 per cent of their net assets, Rowan told the investors. Internally, it has reviewed software companies to assess their potential risks from AI.

Financial Times


Oracle's earnings last week showed that they remain full speed ahead on GPU deployment… 

“In the last quarter, we handed over close to 400 megawatts of data center capacity to our customers. We also delivered 50% more GPU capacity this quarter than Q1...In terms of the results for Q2, we had another excellent quarter of execution. Remaining performance obligations, or RPO, ended the quarter at $523.3 billion, up 433% from last year and up $68 billion since the end of August, driven by contracts signed with Meta, NVIDIA and others as we continue to diversify our customer backlog...We now expect fiscal 2026 CapEx will be about $15 billion higher than we forecasted after Q1.” – Oracle EVP Douglas Kehring

The Transcript


But investors were not happy with Oracle's reporting… 

Unfortunately, the company is now the levered public equity thermometer for investors. Some want to bet big on AI and some want to bet against it. Oracle is now the ticket that traders are using. For the stock to find a bottom, OpenAI will need to crush it and Oracle will need to rapidly diversify its AI customer base.

After five decades of selling enterprise software, Oracle has amassed a lot of very large customers. But never before has the company’s fate hinged so closely on just one.

A lot has happened in the three months since the world learned of Oracle’s deal to provide $300 billion worth of artificial-intelligence computing services to OpenAI. That was just one in a string of expensive deals signed by the ChatGPT parent, which currently generates less than $20 billion in annual revenue…

The biggest surprise turned out to be the wrong kind. Oracle spent a record $12 billion in capital expenditures in the November-ended quarter, which was far higher than the $8.4 billion Wall Street was expecting. It also boosted its full-year capital-expenditure forecast from $35 billion to $50 billion. Oracle’s downtrodden stock lost another 12% in after-hours trading Wednesday.

An annual capex bill of $50 billion might seem light relative to what some of the other big tech companies are sending out the door. But that equates to 75% of Oracle’s projected revenue for the current fiscal year, a staggering amount considering that capex has averaged about 17% of annual revenue over the past five years.

WSJ

Stockcharts.com


If you want a deep dive into AI, this is a good deck that will have you jotting down some notes…

The 2025 State of AI Report from Air Street Capital is a good read for anyone investing into the wave. Below are their 2026 predictions which will get your mind running with ideas. Half of their 2025 predictions hit while half of their misses will likely hit in 2026. My fingers are crossed for a hit on prediction #3.

Air Street Capital


J.P. Morgan doesn't want you to forget about AI's demand on electricity… 

Despite being a small part of the economy, the AI data center build-out has quietly become a key driver of growth this year. While many households have not felt this boom directly, they are likely to feel its knock-on effects, particularly in their utility bills.

As the chart shows, electricity inflation tracked CPI over the past decade, but in the last five years it has accelerated ahead. This shift reflects a surge in demand, driven partly by broader electrification but increasingly by power-hungry AI infrastructure. Data centers have existed for years, but AI facilities are far more energy-intensive: a single AI search can consume around 10 times more energy than a basic web search. After growing about 0.5% annually over the two decades through 2020, conservative estimates project that electricity demand will grow more than thrice as fast this decade. On the supply side, although the administration has declared an “energy emergency,” paving the way for more fossil fuels and even nuclear power plants, these projects will take time to come online.

Meanwhile, consumers could face higher near-term inflation as there’s a risk of a repeat of what auto insurance did in 2023-24: despite its modest weight, it became a sticky source of inflation. Electricity has a similar weight and, like auto insurance, is subject to regulatory pass-throughs that allow higher costs to be passed on to consumers.

JP Morgan


Who will be the next king of the AI mountain? 

The competitive positioning among leading model developers has shifted notably over the past year. Although OpenAI's GPT models had historically led most public benchmarks, LMArena data indicates that Google's Gemini surpassed GPT earlier this year, reflecting how incremental architectural changes and data improvements can meaningfully influence rankings even within a single release cycle (Exhibit 6). As LMArena aggregates large-scale, head-to-head human evaluations across thousands of prompts, we believe movement at the top of its leader board is a reliable signal of model usefulness and popularity among consumers.

Goldman Sachs


Couldn't agree more… 


AI is going to lead to lower head count… 

“When people say that whether AI is an opportunity to drive significant increases in efficiency and what it’s going to do potentially to headcount. It is extremely significant. And anyone who doesn’t say that is just either doesn’t know what they’re talking about, most people do, but they’re afraid to say it. because no one wants to stand up and say that we should have -- we’re going to have lower headcount in the future. It’s a difficult thing to say. Now it doesn’t mean that it’s going to happen next year, and it doesn’t mean that it’s going to happen in every area of the company, right?” – Wells Fargo & Company CEO Charles Scharf

The Transcript


Will Time's cover become a notable peak event or just a timely shout out? 

@KevRGordon: Time's people of the year are the architects of AI


As BofA Global notes, past bubbles are typically front run by a tightening in financial conditions (which we do not have)… 

BofA Global


And now a great long read from the master of bubble studies, Howard Marks… 

Alan Greenspan’s phrase, mentioned earlier, serves as an excellent way to sum up a stock market bubble: “irrational exuberance.” There is no doubt that investors are applying exuberance with regard to AI. The question is whether it’s irrational. Given the vast potential of AI but also the large number of enormous unknowns, I think virtually no one can say for sure. We can theorize about whether the current enthusiasm is excessive, but we won’t know until years from now whether it was. Bubbles are best identified in retrospect.

While the parallels to past bubbles are inescapable, believers in the technology will argue that “this time it’s different.” Those four words are heard in virtually every bubble, explaining why the present situation isn’t a bubble, unlike the analogous prior ones. On the other hand, Sir John Templeton, who in 1987 drew my attention to those four words, was quick to point out that 20% of the time things really are different. But on the third hand, it must be borne in mind that behavior based on the belief that it’s different is what causes it to not be different!

Today’s situation calls to mind a comment attributed to American economist Stuart Chase about faith. I believe it’s also applicable to AI (as well as to gold and cryptocurrencies):
"For those who believe, no proof is necessary. For those who don't believe, no proof is possible"…

Since no one can say definitively whether this is a bubble, I’d advise that no one should go all-in without acknowledging that they face the risk of ruin if things go badly. But by the same token, no one should stay all-out and risk missing out on one of the great technological steps forward. A moderate position, applied with selectivity and prudence, seems like the best approach.

Oaktree Capital


Who needs AI or Mag-7? European Bank stock investors crushed it in 2025… 

The group escaped credit problems, got focused on expenses, and returns on capital with many names buying back equity. Investors were rewarded with higher earnings and returned the favor by increasing the group's price to book values.

Google Finance


Small Cap investors might be lining up to ring a future bell given how badly profitable small caps have underperformed large caps… 

November 3rd was a day that will be remembered by small cap managers as their rolling 3-year return was 6,000 basis points behind the large cap index. Now where is that baton?

Ycharts.com


CAIS and Mercer released their new Alts survey last week… 

Always interesting to see how advisors are positioning their client portfolios into the multiple asset classes.

CAIS Group


Speaking of Private Credit, BofA Global noting how they view the current concerns as overblown… 

Investors that have lived through the 2008 Global Financial Crisis and the late 90s tech bubble are programmed to be wary of industries with high growth. This sensitivity was exploited by the media which has had a negative bias on the Alt managers. However, private credit is not a black box and the underlying credit trends in the public and private BDCs remain solid while the two large corporate defaults (First Brands, Tricolor) were bank-originated (not asset manager) and HPS’s default was fueled by fraud in the non-sponsored market. We remind investors that private credit LTVs are low, spreads are rich, and these portfolios are generally overweight sponsored deals and non-cyclical industries.

BofA Global


The largest player in Private Credit also continues its defense of the asset class… 

The CEO of Apollo Group, Marc Rowan, has continued to hit the road and microphones with a fact-filled slide deck to help separate facts from fiction. It is a worthwhile read if you own public debt or even public equities. Pay close attention to the performance charts of private credit during economically stressed environments. If I could pick only one chart to summarize the entire 125 pages, it would be the one below. So, if you don't need to have the 100% potential liquidity of public bonds, why wouldn't you have exposure to private credit like many long-term oriented institutional investors?

Apollo Group


And with most public credit sectors so richly priced, would investors want to consider private credit? 

The Daily Shot


With the Swiss Franc at all-time highs, their companies are using its strength for M&A deal activity…

Switzerland is heading for a record year for mergers and acquisitions, with deals spanning industries despite a surging franc that has made its companies some of the most expensive targets in Europe.

New data shows that Swiss groups have been involved in M&A activity worth more than $163bn so far in 2025. Deals targeting Swiss companies also hit their highest level since 2018.

“It was a very good year, and with some significant deals being announced,” said Olof Engelbrekts, head of investment banking for Switzerland at Bank of America.

The flurry of deals has continued despite currency moves, with the Swiss franc up 14 per cent against the dollar since January and slightly stronger against the euro.

Financial Times


Beyond Switzerland, the rest of the world is also entering an M&A frenzy… 

Global transaction values have risen around 40% to about $4.5 trillion this year, data compiled by Bloomberg show, as companies chase ultra-ambitious combinations, emboldened by friendlier regulators. That’s the second-highest tally on record and includes the biggest haul of deals valued at $30 billion or more.

“There’s a sentiment in boardrooms and among CEOs that this is a potential multi-year window where it’s possible to dream big,” said Ben Wallace, co-head of Americas M&A at Goldman Sachs Group Inc. “We’re at the beginning of a rate-cutting cycle so there’s anticipation that there will be more liquidity.”…

“When you look around and you see your peers doing these big deals and taking advantage of the tailwinds, you don’t want to be left out,” said Maggie Flores, partner at law firm Kirkland & Ellis LLP in New York. “The regulatory environment is in a position that is very conducive to dealmaking and people are taking advantage of it.”

Bloomberg


Even middle-market M&A has been picking up…

“And the other thing that we’re just recently seeing, which is a bit of a change, and this is just this quarter, is we’re starting to see increased activity with strategic middle market buyers and M&A. They’ve really been on the sidelines all year because of tariffs. You know, private equity was transacting, and large deals were getting transacted. We haven’t seen a lot of bank deal funding for middle market M&A, and that’s kinda just picked up this quarter, which bodes well for next year.” – PNC Financial Services Group CEO William Demchak

The Transcript


It was a quieter M&A week as the holidays approached. But AIG talking to Chubb? Ice up some bubbly! 

  • ServiceNow Inc. (NOW) is in advanced talks to buy the cybersecurity startup Armis in a deal that may be valued at as much as $7 billion and would represent the tech company’s largest acquisition to date. Founded by veterans of Israeli military cyber intelligence, San Francisco-based Armis specializes in identifying and tracking security threats on devices, working across a range of industries, including medical, financial services and defense. In early August, Armis’ chief executive officer, Yevgeny Dibrov, said the company had reached $300 million in annual recurring revenue, up from $200 million a year ago, and that it was still eyeing a public listing in 2026.
  • U.S. drug distributor Cencora (COR) said it will take majority control of cancer care network OneOncology in a $5 billion deal, accelerating its push to provide more services to cancer clinics. Cencora, which already owns a stake in OneOncology, will buy most of the remaining shares from investment firm TPG and other holders for about $3.6 billion in cash and pay off $1.3 billion of OneOncology's debt, for total cash consideration of about $5 billion. The deal, which values OneOncology at $7.4 billion, also provides Cencora synergies in specialty drugs for complex conditions like cancer - a segment which offers high margins and has seen a surge in demand.
  • A joint venture between Blackstone Inc.’s real estate business, MW Group and DivcoWest struck a deal to purchase a Hawaiian commercial property owner Alexander & Baldwin Inc. (ALEX) in a $1.5 billion all-cash deal. The buyers agreed to pay $21.20 a share for the company. Including debt, the enterprise value of the transaction, which is expected to be completed in the first quarter, is about $2.3 billion. A&B, which traces its roots back 155 years to sugar growers on Maui, owns roughly 4 million square feet (372,000 square meters) of commercial real estate, including shopping centers with a grocery store tenant. The company will retain its headquarters in Honolulu.
  • SK Capital Partners has agreed to buy a majority stake in Swixx Biopharma in a deal that values the Swiss drug distribution company at more than €1.5 billion.

Various News Sources


And interesting to see Diamond Hill decide that being private will be better than being public. They have been in the game a long time… 

First Eagle Investments has agreed to acquire Diamond Hill Investment Group, Inc. (NASDAQ:DHIL) for $175 per share in an all-cash transaction valuing the company at approximately $473 million, according to a press release statement. Diamond Hill, which currently has a market cap of about $318 million, has been profitable over the last twelve months with a healthy return on equity of 27%.

The purchase price represents a 49% premium over Diamond Hill’s closing share price on December 10, 2025, and a 44% premium over the company’s 30-day volume-weighted average price. Notably, the offer price closely aligns with InvestingPro’s Fair Value estimate, suggesting the acquisition appropriately values the company, which has been trading at a low P/E ratio of just 6.8 and near its 52-week low of $114.11.

Following the transaction, Diamond Hill will maintain its Columbus headquarters and continue operating under its existing brand with no changes to its investment philosophy or process. The deal is expected to enhance First Eagle’s footprint in traditional fixed income, an area of significant growth for Diamond Hill in recent years.

Investing


Diamond Hill's 27-year chart versus the as old competition… 

Over 27 years, only AMG has beaten the S&P 500 as Index ETF competition and margin compression has hurt the active asset management industry.

Ycharts.com


Fewer public companies to invest into plus faster growing companies remaining private has left the SEC in a quandary… 

For most Americans, the universe of stocks they can invest in is rapidly shrinking. The number of public companies in the U.S. is half of its peak in the late 1990s.That’s not a problem for the rich.

The ultrawealthy are able to buy and sell shares of the buzziest private companies via invite-only transactions long before they list their shares on public stock exchanges.

That’s created a two-tier market. One tier is a private club of sorts, where a privileged group can obtain shares of companies still in their early growth stages. Everyone else is left with older, slower-growing names. The dynamic is exacerbating the wealth disparity in the U.S., as the growth in the net worth of the richest Americans is far outpacing all other income groups.

Some policymakers and economists see this as an existential threat to the U.S. economy. The most powerful critic is the chairman of the Securities and Exchange Commission, Paul Atkins. Atkins is trying to entice more companies to go public and trying to open up access to private markets to a much wider group of investors.

Young companies like Intel and Apple decades ago sold shares to the public to raise money to hire employees, build factories and fund development of new products, Atkins says. “Insiders got returns, obviously, but the public really shared in those,” Atkins said. “Nowadays it’s completely reversed.”

WSJ


Speaking of private companies that have been inaccessible to all investors… 

SpaceX, the rocket and satellite maker run by Elon Musk, told employees on Friday that it would buy insider shares in a deal that would value it at around $800 billion, and said that it was preparing for a potential initial public offering next year.

In a letter to employees and other shareholders, Bret Johnsen, SpaceX’s chief financial officer, said the company and investors planned to buy $2.56 billion of shares from stockholders at $421 a share, nearly double its previous internal share price. Mr. Johnsen also alluded to a possible public offering in the letter, which was obtained by The New York Times.

“Whether it actually happens, when it happens, and at what valuation are still highly uncertain, but the thinking is that if we execute brilliantly and the markets cooperate, a public offering could raise a significant amount of capital,” he wrote.

The offer to buy shares from employees would make SpaceX the world’s most valuable private company, outstripping the A.I. company OpenAI, which is currently valued at around $500 billion. If and when SpaceX goes public, it would likely be one of the largest ever public listings, and an enormous wealth creation event for shareholders.

NY Times


But maybe there will be an IPO tidal wave in 2026… 

It normally takes a lot more than three companies to create an initial public offering boom. But if those three companies are SpaceX, OpenAI and Anthropic, Wall Street may soon find itself in the middle of an IPO boom for the ages.

In one of the first clear signs that some of the most valuable private tech companies have set the wheels in motion to go public, the Financial Times last week reported Anthropic had appointed lawyers to lay the groundwork. That puts it a step ahead of OpenAI, which is also considering an IPO. Reports in recent days, first by Bloomberg, suggest Elon Musk’s rocket company SpaceX is also gearing up to go public.

It’s not hard to see why. Private equity investors have provided huge amounts of capital for these companies, but they have their limits. OpenAI has raised $41bn of equity this year and will need much more before turning a profit. SpaceX is reported to be planning to raise more than $30bn in an IPO.

They would fill a useful niche for public market investors. As pure-play model builders, OpenAI and Anthropic would provide a new way for Wall Street to bet on artificial intelligence. And SpaceX, which accounted for more than half of all rocket launches last year, would be unrivalled as a wager on the future space economy.

If all three go public at roughly the same time, possibly next year, it would be an extraordinary moment for Wall Street. The headline numbers would be head-spinning. SpaceX is hoping to be valued at $800bn in its latest private share sale, while Anthropic is targeting $350bn. OpenAI’s most recent share sale was at $500bn.

Financial Times


It looks like 2026 will be a very good year to be an Eli Lilly pharma rep… 

Eli Lilly said its next generation weight-loss drug retatrutide helped people lose up to 28.7% of their body weight after more than a year of treatment, significantly more than what existing drugs can provide…

Retatrutide is in the same general category as Novo Nordisk’s Ozempic and Wegovy and Lilly’s own Mounjaro and Zepbound. It works by mimicking three gut hormones, which helps regulate appetite and can increase a person’s energy expenditure.

Lilly conducted a Phase 3 trial of retatrutide in patients with obesity and knee osteoarthritis, and who didn’t have diabetes. The baseline body-mass index of patients was at least 35 at the start of the trial, a relatively high level of obesity. They were given weekly shots of the drug or a placebo for 68 weeks.

Those taking the highest dose of retatrutide lost an average of 71.2 pounds, or 28.7% of their body weight.

In comparison, the highest dose of Lilly’s Zepbound has been shown to help people lose an average of 22.5% of body weight, and the average weight loss for Novo Nordisk’s Wegovy is under 20%.

WSJ

Abnormal Returns


And finally, here is that chart of equity returns seasonality. Don't forget to leave out the cookies and milk for Santa… 

Goldman Sachs: As we move into the second half of December, seasonality improves with a median return since 1950 of +1.3% up from just +0.3% for the first half, 4th best for all monthly halves.

@neilksethi


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The author has current equity ownership in: J.P. Morgan Chase & Co.

The information presented here is for informational purposes only, and this document is not to be construed as an offer to sell, or the solicitation of an offer to buy, securities. Some investments are not suitable for all investors, and there can be no assurance that any investment strategy will be successful. The hyperlinks included in this message provide direct access to other Internet resources, including Web sites. While we believe this information to be from reliable sources, Hamilton Lane is not responsible for the accuracy or content of information contained in these sites. Although we make every effort to ensure these links are accurate, up to date and relevant, we cannot take responsibility for pages maintained by external providers. The views expressed by these external providers on their own Web pages or on external sites they link to are not necessarily those of Hamilton Lane.

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